Application of Sodium Bis(trimethylsilyl)amide

Product name:Sodium Bis(trimethylsilyl)amide
CAS:1070-89-9
Molecular Formula:C6H18NNaSi2
Formula Weight:183.37g/mol
Description of Sodium Bis(trimethylsilyl)amide:
Application:
NaHMDS is widely used as a base for C-H acids. Typical reactions:
To deprotonate ketones and esters to generate enolate derivatives.
Generate halocarbenes such as CHBr and CHI by dehydrohalogenation of the CH2X2 (X = Br, I). These carbene reagents add to alkenes to give substituted cyclopropanes.
To generate Wittig reagents via deprotonation of phosphonium salts.
Deprotonate cyanohydrins.
NaHMDS is also used as a base for N-H acids.
Appearance:off-white solid
Density :0.9 g/cm3, solid
Melting point:171-175 °C, 444-448 K, 340-347 °F
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